Eukaryotic transcription initiation machinery visualized at molecular level
نویسندگان
چکیده
منابع مشابه
Eukaryotic transcription initiation
Transcription is defined as the synthesis of RNA from a DNA template. In bacteria, transcription of all genes is catalysed by a single RNA polymerase, whereas in the eukaryotic nucleus, three different RNA polymerases — Pol I, Pol II and Pol III — carry out the synthesis of different classes of RNA. Pol I and Pol III transcribe a limited number of genes encoding ribosomal RNAs, transfer RNAs an...
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The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes.
متن کاملRegulation of the initiation of eukaryotic transcription.
DNA sequences that determine transcriptional regulation of a typical eukaryotic gene consist of a core promoter, which serves as a binding site for the GTF TFIID, and regulatory promoter or enhancer sequences, which bind transcriptional activators. The RNA polymerase II transcription machinery consists of over 50 proteins which are thought to bind to the core promoter in as few as two steps: bi...
متن کاملMolecular basis of eukaryotic transcription
The Nobel Prize in Chemistry for 2006 is awarded to Roger Kornberg for his fundamental studies of the molecular basis of eukaryotic transcription. Transcription is the process in a cell in which the genetic information stored in DNA is activated by the synthesis of complementary mRNA by enzymes called RNA polymerases. Eventually, the mRNA is translated by ribosomes into functional cell proteins...
متن کاملMolecular basis of eukaryotic transcription
The Nobel Prize in Chemistry for 2006 is awarded to Roger Kornberg for his fundamental studies of the molecular basis of eukaryotic transcription. Transcription is the process in a cell in which the genetic information stored in DNA is activated by the synthesis of complementary mRNA by enzymes called RNA polymerases. Eventually, the mRNA is translated by ribosomes into functional cell proteins...
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ژورنال
عنوان ژورنال: Transcription
سال: 2016
ISSN: 2154-1264,2154-1272
DOI: 10.1080/21541264.2016.1237150